It is very important to know about what medicine is given by the doctor, for what condition, and when it needs to be taken in what dose. This information given by the doctor is called Prescription. The patients should be familiar with the medicine prescription, and the details about the medicine before purchasing it and using it. Some medications need not be prescribed by healthcare practitioners and can be purchased and used without prescription by the patients; these are called over-the-counter medications. Read the drug prescription information of Unitrexate before taking it.
What is Unitrexate
Unitrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. Unitrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Unitrexate is also used to treat severe psoriasis and rheumatoid arthritis. Unitrexate is usually given after other medications have been tried without successful treatment of symptoms. Unitrexate may also be used for purposes not listed in Unitrexate guide.
Unitrexate side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Unitrexate and call your doctor at once if you have:
dry cough, shortness of breath;
diarrhea, vomiting, white patches or sores inside your mouth or on your lips;
blood in your urine or stools;
swelling, rapid weight gain, little or no urinating;
fever, chills, body aches, flu symptoms;
pale skin, easy bruising, unusual bleeding, weakness, feeling light-headed or short of breath;
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Older adults may be more likely to have side effects from this medicine. Common side effects may include:
vomiting, upset stomach;
headache, dizziness, tired feeling; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. See also: Side effects (in more detail)
Usual Adult Dose for Acute Lymphoblastic Leukemia:
Induction: 3.3 mg/m2/day orally or IM. Maintenance (during remission): 15 mg/m2 IM or orally twice a week. Alternate remission dosing: 2.5 mg/kg IV every 14 days.
Usual Adult Dose for Choriocarcinoma:
15 to 30 mg IM or orally daily for 5 days. Repeat courses 3 to 5 times with a rest period of greater than or equal to 1 week between courses, until any manifesting toxic symptoms subside. Effectiveness of therapy is ordinarily evaluated by 24 hour quantitative analysis of urinary chorionic gonadotropin (hCG), which generally will return to normal or less than 50 intl units/24 hours usually after the third or fourth course and usually followed by a complete resolution of measurable lesions in 4 to 6 weeks. One to two courses of Unitrexate after normalization of hCG is usually recommended.
Usual Adult Dose for Trophoblastic Disease:
15 to 30 mg IM or orally daily for 5 days. Repeat courses 3 to 5 times with a rest period of greater than or equal to 1 week between courses, until any manifesting toxic symptoms subside. Effectiveness of therapy is ordinarily evaluated by 24 hour quantitative analysis of urinary chorionic gonadotropin, which generally will return to normal or less than 50 intl units/24 hours usually after the third or fourth course and usually followed by a complete resolution of measurable lesions in 4 to 6 weeks. One to two courses of Unitrexate after normalization of hCG is usually recommended.
Usual Adult Dose for Lymphoma:
For Burkitt's tumor in Stages I-II: 10 to 25 mg orally once a day for 4 to 8 days Malignant lymphoma in Stage III: 0.625 to 2.5 mg/kg orally daily as a part of combination chemotherapy. Treatment in all stages usually consists of several courses of the drug interposed with 7 to 10 day rest periods.
Usual Adult Dose for Meningeal Leukemia:
12 mg/m2 intrathecally every 2 to 5 days until the cell count of the CSF returns to normal. At this point, one additional dose is advisable. Administration at intervals of less than 1 week may result in increased subacute toxicity.
Usual Adult Dose for Mycosis Fungoides:
2.5 to 10 mg PO daily or 50 mg IM once a week or 25 mg IM twice a week.
Usual Adult Dose for Osteosarcoma:
Initial Dose: 12 g/m2 intravenously as a 4 hour infusion. If this dose is not adequate to achieve a peak serum concentration of 1000 micromolar at the end of the infusion, the dose may be increased to 15 g/m2. Treatments may occur at 4, 5, 6, 7, 11, 12, 15, 16, 29, 30, 44, and 45 weeks after surgery. If the patient is vomiting or unable to tolerate oral medication, leucovorin should be added to this regimen at the same dose and schedule as the Unitrexate.
Usual Adult Dose for Psoriasis:
Single Dose: 10 to 25 mg/week orally, subcutaneously, IM, or IV until adequate response is achieved. Divided Dose: 2.5 mg orally, IM, or IV every 12 hours for 3 doses once a week. Maximum weekly dose: 30 mg.
Usual Adult Dose for Rheumatoid Arthritis:
Single dose: 7.5 mg orally weekly. Divided dose: 2.5 mg orally every 12 hours for 3 doses once a week. Maximum weekly dose: 20 mg Patients may be switched from oral Unitrexate to weekly subcutaneous injections taking into account the increased bioavailability relative to the oral formulation.
Usual Adult Dose for Neoplastic Diseases:
I.V.: Range is wide from 30-40 mg/m2/week to 100-12,000 mg/m2 with leucovorin rescue
Usual Pediatric Dose for Acute Lymphocytic Leukemia:
100 mg/m2 over 1 hour followed by a 35 hour infusion delivering 900 mg/m2/day.
Usual Pediatric Dose for Dermatomyositis:
15 to 20 mg/m2 orally once weekly.
Usual Pediatric Dose for Meningeal Leukemia:
less than 4 months: 3 mg/dose intrathecally. greater than or equal to 4 months less than 1 year: 6 mg/dose intrathecally. greater than or equal to 1 year less than 2 years: 8 mg/dose intrathecally. greater than or equal to 2 years less than 3 years: 10 mg/dose intrathecally. greater than or equal to 3 years: 12 mg/dose intrathecally. The dose may be administered every 2 to 5 days until CSF counts return to normal followed by a dose administered once weekly for 2 weeks and monthly thereafter. Administration at intervals of less than 1 week may result in increased subacute toxicity.
Usual Pediatric Dose for Neoplastic Diseases:
7.5 to 30 mg/m2 IM or orally every 2 weeks. Alternate dosing: 10 to 18,000 mg/m2 IV bolus or continuous infusion over 6 to 42 hours.
Usual Pediatric Dose for Rheumatoid Arthritis:
5 to 15 mg/m2 IM or orally once weekly. Subcutaneous injection for Polyarticular Juvenile Idiopathic Arthritis: 10 mg/m2 subcutaneously once weekly.
Usual Pediatric Dose for Solid Tumors:
less than 12 years: 12000 mg/m2 IV. greater than or equal to 12 years: 8000 mg/m2 IV. Maximum dose: 18 grams.
Dailymed."Methotrexate sodium: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
Can Unitrexate be stopped immediately or do I have to stop the consumption gradually to ween off?
In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.
It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.
Who should not take Unitrexate?
You should not use this medicine if you are allergic to Unitrexate. Do not use Unitrexate to treat psoriasis or rheumatoid arthritis if you have:
alcoholism, cirrhosis, or other liver disease;
a blood cell disorder such as anemia or leukopenia (lack of white blood cells);
a bone marrow disorder; or
if you are breast-feeding a baby.
Unitrexate is sometimes used to treat cancer even when patients do have one of the conditions listed above. Your doctor will decide if this treatment is right for you.
To make sure Unitrexate is safe for you, tell your doctor if you have:
a folate deficiency;
pneumonia or lung disease;
any type of infection; or
if you are receiving radiation treatments.
Unitrexate can cause birth defects in an unborn baby. Do not use Unitrexate to treat psoriasis or rheumatoid arthritis if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
You may need to have a negative pregnancy test before starting this treatment.
Use birth control to prevent pregnancy while you are using Unitrexate, whether you are a man or a woman. Unitrexate use by either parent may cause birth defects.
If you are a man, use a condom to keep from causing a pregnancy while you are using Unitrexate. Continue using condoms for at least 90 days after your treatment ends.
If you are a woman, use an effective form of birth control while you are taking Unitrexate, and for at least one cycle of ovulation after your treatment ends.
Do not give this medicine to a child without the advice of a doctor.
How should I take Unitrexate?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
You must use the correct dose of Unitrexate for your condition. Unitrexate is sometimes taken once or twice per week and not every day. Follow the directions on your prescription label. Some people have died after taking Unitrexate every day by accident. Ask your doctor or pharmacist if you have questions about your dose of Unitrexate or how often to take it.
Use Unitrexate regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Unitrexate can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often, and you may need an occasional liver biopsy. Your cancer treatments may be delayed based on the results of these tests.
Store at room temperature away from moisture and heat.
What other drugs will affect Unitrexate?
Many drugs can interact with Unitrexate. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Unitrexate, especially:
an antibiotic or sulfa drugs;
isotretinoin, retinol, tretinoin;
NSAIDs (non-steroidal anti-inflammatory drugs)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or
This list is not complete and many other drugs can interact with Unitrexate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Can Unitrexate be taken or consumed while pregnant?
Please visit your doctor for a recommendation as such case requires special attention.
Can Unitrexate be taken for nursing mothers or during breastfeeding?
Kindly explain your state and condition to your doctor and seek medical advice from an expert.
Following the study conducted by gmedication.com on Unitrexate, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Unitrexate. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.
Patient reported useful
No survey data has been collected yet
One patient reported side effects
Does the Unitrexate Have Any Side Effects? Based on the survey report from users of gmedication.com, about No side effects number of people suffered some side effect after consumption of Unitrexate. All drugs have a portion of undesirable side effects. These effects could be irritations too insignificant for the patient to even notice. However, the side effects of drugs may be determined by several factors like severity of disease and conditions associated with individual patients. However, one of the biggest factors is the dosage consumed. The higher the quantity taken by an individual, the greater the healing effect and the corresponding side effect. All patients have their different intensity of side effects. Ensure you consult your health care provider immediately you notice an unusual side effect affect the consumption of Unitrexate.
No side effects
One patient reported price estimates
Do you think The Price of Unitrexate is Worth It? Do you feel you paid higher than the value you got from it after usage? According to reports from gmedication.com users, on whether the Unitrexate medicine is affordable, users shared different opinions on the question. The views concerning the price of the medicine were based on some factors like the brand the patient bought, the price compared to its level of effectiveness, the nation or country where the medicine is sold, and the amount of money the patient has. For users who are of the opinion that the medicine is unaffordable, they may have to consider a medicine with another brand in a bid to reduce cost.
One patient reported frequency of use
How often should I take Unitrexate? According to the survey, gmedication.com reported that users of Unitrexate should take Twice in a day as the primarily recommended frequency. However, patients are advised to follow the dosage as prescribed by their physician religiously. To get the opinions of other patients on the ideal consumption frequency of the medicine, click here.
Twice in a day
Seven patients reported doses
What is the specific doses you have used? Unitrexate May come in various doses. In most cases, antibiotics, antihypertensive, pain killers and anti-diabetic drugs available in different doses. Your doctor may prescribe any of the doses based on the severity of the patient's condition. According to our reports, users of gmedication.com used the drugs in the following dosage percentage (Provide dosage percentage). Only a handful of drugs are made in a single or fixed dose. Regular health conditions like fever have similar doses. For instance [acetaminophen, 500mg] was used by the patients surveyed although it comes in different doses.
Patient reported time for results
No survey data has been collected yet
One patient reported administration
When is the best condition to take Unitrexate: Before or after food? Based on the survey, the users of gmedication.com voted that Unitrexate is best taken at With a meal. It is however worthy of mention that this popular vote may not be an appropriate description for your particular health condition. See your doctor for professional medical advice as regards the best time to take this medicine. If you wish to see the views of other users on the best time to take the medicine, simply click here.
With a meal
Four patients reported age
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