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What is Setinin SR

Setinin SR is an antipsychotic medicine. It works by changing the actions of chemicals in the brain.
Setinin SR is used to treat schizophrenia in adults and children who are at least 13 years old.
Setinin SR is used to treat bipolar disorder in adults and children who are at least 10 years old.
Setinin SR is also used together with antidepressant medications to treat major depressive disorder in adults.
Extended-release Setinin SR (Seroquel XR) is for use only in adults and should not be given to anyone younger than 18 years old.
Setinin SR may also be used for purposes not listed in Setinin SR guide.

Setinin SR side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive, more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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Setinin SR dosing

Usual Adult Dose for Schizophrenia:

Immediate-release tablets:
Initial Dose: 25 mg orally twice a day.
The dosage may be increased in increments of 25 to 50 mg two times a day or three times a day on the second and third days. By the fourth day a dosage range of 300 mg to 400 mg daily (divided into 2 or 3 doses a day) may be achieved. Additional dosage adjustments (increases or decreases) of 25 to 50 mg twice a day may be made, as needed. However, at least 2 days should pass between the additional dosage adjustments.
Efficacy in schizophrenia has been reported with doses ranging from 150 to 750 mg/day. Maximum clinical effect has been reported at 300 mg/day. The safety of doses above 800 mg/day has not been evaluated in clinical trials.
Extended-release tablets:
Initial dose: 300 mg orally once daily without food or with a light meal.
Maintenance dose: 400 to 800 mg orally once daily depending on response and tolerance.
Maximum dose: Doses above 800 mg daily have not been studied.
The dosage of the extended-release tablets may be increased in increments of up to 300 mg daily at intervals as short as 1 day.
The efficacy of Setinin SR in long-term use (over 6 weeks) has not been studied in clinical trials. Patients who respond favorably to Setinin SR may be continued on the lowest dose which is effective in maintaining their remission. Patients should be periodically reassessed to determine their need for maintenance treatment.

Usual Adult Dose for Bipolar Disorder:

Immediate-release tablets:
Mania associated with bipolar I disorder as monotherapy or as adjunct therapy to lithium or divalproex:
Initial Dose: 50 mg orally twice a day
The dose may be increased to 200 mg orally twice daily on day 4 in increments of up to 50 mg twice daily. Further dosage adjustments up to 800 mg per day by day 6 should be in increments of no greater than 200 mg/day. Data has been reported to indicate that the majority of patients responded between 400 mg per day to 800 mg per day. The safety of doses above 800 mg per day has not been evaluated in clinical trials.
Immediate-release tablets:
Depressive episodes associated with bipolar disorder:
Initial dose: 50 mg orally once a day
The dose may be increased to reach 300 mg orally once a day by day 4. Some patients may require a further increase to 600 mg once a day by increasing the daily dose to 400 mg on day 5 and 600 mg on day 8 of treatment. Efficacy was demonstrated in this patient population at both 300 mg and 600 mg per day. However, no additional benefit was observed in patients receiving 600 mg per day as compared to those patients receiving 300 mg per day.
Extended-release tablets:
Bipolar Depression:
(Depressive Episodes Associated with Bipolar Disorder)
Usual dose for Acute Treatment: administer orally once daily in the evening starting with 50 mg per day and increasing doses to reach 300 mg per day by day 4.
Recommended Dosing Schedule: Day 1 - 50 mg, Day 2 - 100, mg, Day 3 - 200 mg, & Day 4 - 300 mg
Bipolar Mania:
Usual dose for Acute Monotherapy or Adjunct Therapy (with lithium or divalproex): administer orally once daily in the evening starting with 300 mg on day 1, 600 mg on day 2, and adjust between 400 mg and 800 mg per day thereafter depending on the clinical response and tolerance of the individual patient.
Bipolar Maintenance:
Continue treatment at the dosage required to maintain symptom remission.
While there is no body of evidence available to specifically address how long patients should remain on Setinin SR extended-release tablets, maintenance of efficacy in Bipolar I Disorder has been demonstrated with Setinin SR (administered orally twice daily totaling 400 to 800 mg per day) as adjunct therapy to lithium or divalproex. Generally, in the maintenance phase, patients continued on the same dose on which they were stabilized during the stabilization phase. Patients should be periodically reassessed to determine the need for maintenance treatment and the appropriate dose for such treatment.

Usual Adult Dose for Depression:

As adjunctive therapy to antidepressants for use in the treatment of major depressive disorder:
Extended-release tablets:
Initial dose: 50 mg orally once daily in the evening
On day 3, the dose can be increased to 150 mg once daily in the evening.
Range: 150 mg to 300 mg orally daily. Doses above 300 mg have not been studied.

Usual Geriatric Dose for Schizophrenia:

Immediate-release tablets:
Initial Dose: 25 mg orally once a day.
The dose may be increased daily in increments of 25 mg/day to 50 mg/day to an effective dose, depending on the clinical response and tolerability of the patient.
Efficacy in schizophrenia has been reported with doses ranging from 150 to 750 mg/day. Maximum clinical effect has been reported at 300 mg/day. The safety of doses above 800 mg/day has not been evaluated in clinical trials.
Extended-release tablets:
When an effective immediate-release dose has been reached, the patient may be switched to the extended-release formulation at an equivalent dose.
The efficacy of Setinin SR in long-term use (over 6 weeks) has not been studied in clinical trials. Patients who respond favorably to Setinin SR may be continued on the lowest dose which is effective in maintaining their remission. Patients should be periodically reassessed to determine their need for maintenance treatment.

Usual Geriatric Dose for Bipolar Disorder:

Extended-release tablets:
Initial dose: 50 mg/day
The dose can be increased in increments of 50 mg/day depending on the response and tolerance of the individual patient.

Select the most affordable brand or generic drug


StrengthQuantityPrice, USDCountry
100 mg100 Tablet$5.60
Conquet 25 mg Tablet $0.03
Conquet 100 mg Tablet $0.06
Conquet 200 mg Tablet $0.11
25 mg10 Tablet$0.25
50 mg10 Tablet$0.49
Queticare 50 mg Tablet $0.05
QUETICARE tab 50 mg x 10's $0.49Symbiosis (Polaris)
50 mg x 100's $4.90
Queticare 50mg TAB / 100 $4.90
Queticare 100 mg Tablet $0.09
QUETICARE tab 100 mg x 10's $0.91Symbiosis (Polaris)
100 mg x 100's $9.10
Queticare 100mg TAB / 100 $9.10
Quser 200mg Tablet XL $0.16Icon Life Sciences
Quser 50mg Tablet $0.07Icon Life Sciences
Quser 100mg TAB / 10 $0.73
QUTACE SR 200MG TABLET 1 strip(s) (10 tablets each) $1.41La Pharmaceuticals
Qutace 25mg Tablet $0.04La Pharmaceuticals
Qutace 50 mg Tablet $0.04
Qutace 100 mg Tablet $0.07
Qutace 100mg Tablet $0.08La Pharmaceuticals
200 mg x 10's $1.17
Qutipin 200 mg Tablet $0.15
Qutipin 200mg TAB / 10 $1.44
QUTIPIN 200 MG TABLET 1 strip(s) (10 tablets each) $1.79Sun Pharma Laboratories Ltd
Qutipin 300mg Tablet $0.24Sun Pharmaceutical Industries Ltd
Qutipin 400mg Tablet SR $0.34Sun Pharmaceutical Industries Ltd
QUTIPIN tab 25 mg x 10's $0.45Sun (Symbiosis)
QUTIPIN 25 MG TABLET 1 strip(s) (10 tablets each) $0.61Sun Pharma Laboratories Ltd
QUTIPIN Capsule/ Tablet / 100mg (10 units) $0.70Sun Pharmaceuticals (Symbiosis Division)
QUTIPIN 50 MG TABLET SR 1 strip(s) (10 tablet srs each) $0.83Sun Pharma Laboratories Ltd
Qutipin 100mg Tablet SR $0.11Sun Pharmaceutical Industries Ltd
100 mg30 $92.00Australia, Canada, India, Mauritius, NZ, Singapore, Turkey, UK
100 mg60 $115.00Barbados, Canada, NZ, UK
100 mg90 $64.64Australia, Canada, India, NZ, Singapore, Turkey, UK, USA
100 mg90 $74.00Australia, Canada, NZ, Singapore, UK
100 mg90 $109.90Australia, Canada, NZ, Singapore, Turkey
100 mg90 $111.99Canada, Mauritius, Singapore, Turkey, UK, USA
100 mg100 $738.37USA
150 mg60 $245.20Barbados, Canada, NZ, UK
200 mg30 $58.50Australia, Canada, India, NZ, Singapore, Turkey, UK, USA
200 mg30 $84.00Australia, Canada, India, Mauritius, NZ, Singapore, Turkey, UK
200 mg30 $113.00Australia, Canada, India, Mauritius, NZ, Singapore, Turkey, UK, USA
200 mg60 $237.15Canada, UK
200 mg90 $81.70Australia, Canada, India, NZ, Singapore, Turkey, UK, USA
200 mg90 $93.00Australia, Canada, India, Mauritius, NZ, Singapore, Turkey, UK, USA
200 mg90 $93.00Australia, Canada, Mauritius, NZ, Singapore, Turkey, UK, USA
200 mg90 $175.00Australia, Canada, Mauritius, NZ, Singapore, Turkey, UK, USA
25 mg30 $32.90Australia, Canada, India, NZ, Singapore, Turkey, UK, USA
25 mg60 $61.75Canada, UK
25 mg90 $47.60Canada, India, NZ, Singapore, Turkey, UK, USA
25 mg90 $47.85Australia, Canada, India, NZ, Singapore, Turkey, UK, USA
25 mg90 $67.00Australia, Canada, India, Mauritius, NZ, Singapore, Turkey, UK, USA
25 mg90 $84.60Australia, Canada, India, Mauritius, NZ, Turkey, Singapore, UK, USA
25 mg100 $89.18Canada, UK
300 mg30 $124.00Australia, Canada, India, Mauritius, NZ, Singapore, Turkey, UK, USA
300 mg60 $86.80Australia, Canada, India, NZ, Singapore, Turkey, UK, USA
300 mg60 $98.00Australia, Canada, Mauritius, NZ, Singapore, Turkey, UK, USA
300 mg60 $289.00Australia, Canada, India, Mauritius, NZ, Turkey, Singapore, UK, USA
300 mg60 $336.52Canada, UK
300 mg90 $1.00USA
300 mg90 $444.51Australia, Canada, NZ, Singapore, Turkey, UK, USA
300 mg100 $565.00Canada, Mauritius, NZ, Singapore, Turkey, UK, USA
300 mg100 $927.54Barbados, Canada, NZ, UK
400 mg60 $421.34Canada, UK
400 mg90 $1.00USA
50 mg30 $215.99Canada, Mauritius, Singapore, Turkey, UK, USA
50 mg100 $708.99Canada, Mauritius, Singapore, Turkey, UK, USA
Seroquel 200 mg x 60's $216.34
Seroquel 200 mg x 6 x 10's $105.89
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References

  1. Dailymed."Quetiapine fumarate: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "Quetiapine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "Quetiapine". http://www.drugbank.ca/drugs/DB0122... (accessed August 28, 2018).

Setinin SR - Frequently asked Questions

Can Setinin SR be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

What other drugs will affect Setinin SR?

Taking Setinin SR with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking Setinin SR with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Many drugs can interact with Setinin SR. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Setinin SR, especially:

This list is not complete and many other drugs can interact with Setinin SR. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Who should not take Setinin SR?

You should not use Setinin SR if you are allergic to it.

Setinin SR is not approved for use in psychotic conditions related to dementia. Setinin SR may increase the risk of death in older adults with dementia-related conditions.

To make sure Setinin SR is safe for you, tell your doctor if you have:

Some young people have thoughts about suicide when first taking Setinin SR. Your doctor will need to check your progress at regular visits while you are using this medicine. Your family or other caregivers should also be alert to changes in your mood or symptoms.

FDA pregnancy category C. It is not known whether Setinin SR will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Setinin SR, do not stop taking it without your doctor's advice.

Setinin SR can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using Setinin SR.

Do not give Setinin SR to a child without a doctor's advice. Extended-release Setinin SR (Seroquel XR) is for use only in adults and should not be given to anyone younger than 18 years old.

How should I take Setinin SR?

Follow all directions on your prescription label. Never take Setinin SR in larger amounts, or for longer than recommended by your doctor. High doses or long-term use of Setinin SR can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include tremors or other uncontrollable muscle movements.

Take this medicine with a full glass of water. You may take Setinin SR with or without food.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Setinin SR may cause you to have high blood sugar (hyperglycemia). Talk to your doctor if you have any signs of hyperglycemia such as increased thirst or urination, excessive hunger, or weakness. If you are diabetic, check your blood sugar levels on a regular basis while you are taking Setinin SR.

You should not stop using Setinin SR suddenly. Stopping suddenly may make your condition worse.

Blood pressure may need to be checked often in a child or teenager taking Setinin SR.

This medication can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking Setinin SR.

Store at room temperature away from moisture and heat.

Can Setinin SR be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Setinin SR be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

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Reviews

Following the study conducted by gmedication.com on Setinin SR, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Setinin SR. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

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The information was verified by Dr. Vishal Pawar, MD Pharmacology