It is very important to know about what medicine is given by the doctor, for what condition, and when it needs to be taken in what dose. This information given by the doctor is called Prescription. The patients should be familiar with the medicine prescription, and the details about the medicine before purchasing it and using it. Some medications need not be prescribed by healthcare practitioners and can be purchased and used without prescription by the patients; these are called over-the-counter medications. Read the drug prescription information of PTA before taking it.
What is PTA
PTA is in a group of drugs called PTA pump inhibitors. It decreases the amount of acid produced in the stomach. PTA is used to treat erosive esophagitis, and other conditions involving excess stomach acid such as Zollinger-Ellison syndrome. PTA is not for immediate relief of heartburn symptoms. PTA may also be used for purposes not listed in PTA guide.
PTA side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using PTA and call your doctor at once if you have symptoms of low magnesium such as:
fast or uneven heart rate;
jerking muscle movements;
feeling jittery;
diarrhea that is watery or bloody;
muscle cramps, muscle weakness or limp feeling;
cough or choking feeling; or
headache, trouble concentrating, memory problems, weakness, loss of appetite, feeling unsteady, confusion, hallucinations, fainting, seizure, or shallow breathing.
Less serious side effects are more likely to occur, such as:
weight changes;
nausea, vomiting, mild diarrhea;
gas, stomach pain;
dizziness, drowsiness, tired feeling;
joint pain; or
sleep problems.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. See also: Side effects (in more detail)
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PTA dosing
Usual Adult Dose for Erosive Esophagitis:
Treatment of Erosive Esophagitis: 40 mg orally once a day for up to 8 weeks; however an additional 8 weeks may be considered for patients who have not healed after the initial treatment. Safety and efficacy beyond 16 weeks of therapy have not been established. Maintenance of Healing of Erosive Esophagitis: 40 mg orally once a day. Controlled studies have been limited to 12 months of PTA therapy.
Usual Adult Dose for Gastroesophageal Reflux Disease:
Parenteral: 40 mg once a day for 7 to 10 days, administered via intravenous infusion over a period of 15 minutes. Intravenous therapy should be discontinued as soon as the patient is able to resume oral therapy. Oral: 40 mg orally once a day, for short-term administration ; however an additional 8 weeks may be considered for patients who have not healed after the initial treatment. Safety and efficacy beyond 16 weeks of therapy have not been established.
Usual Adult Dose for Duodenal Ulcer:
Study (n=54) 40 mg orally once a day, dose was increased every 12 weeks by 40 mg increments to a maximum of 120 mg per day, for 28 weeks. Data have revealed that monotherapy with daily doses of 40 mg have been associated with complete duodenal ulcer healing in up to 87% and 94% of patients after 4 weeks and 8 weeks respectively.
Usual Adult Dose for Gastric Ulcer:
40 mg orally once a day. Data have revealed that monotherapy with daily doses of 40 mg have been associated with complete gastric ulcer healing in up to 87% and 97% of patients after 4 weeks and 8 weeks respectively.
Usual Adult Dose for Helicobacter pylori Infection:
Study - Triple therapy: 40 mg orally twice daily for 7 days, commonly in conjunction with clarithromycin and either amoxicillin or metronidazole to eradicate Helicobacter pylori, followed with 40 mg PTA orally once daily until day 28. Triple therapy has resulted in eradication rates of greater than 95%. The QUADRATE Study (n=405) - Quadruple therapy: 40 mg orally twice daily for 7 days, concomitantly with bismuth subcitrate and tetracycline, both four times daily, and metronidazole 200 mg three times daily and 400 mg at bedtime. Helicobacter Pylori eradication was achieved in 82% of patients.
Usual Adult Dose for Zollinger-Ellison Syndrome:
Parenteral: 80 mg every 12 hours, administered by 15-minute infusion. Daily doses higher than 240 mg administered in equally divided doses by 15-minute infusion, or administered for more than 6 days have not been studied. Oral: 40 mg twice daily, to a maximum of 240 mg per day. Some patients have received treatment with PTA for more than 2 years.
Usual Adult Dose for Stress Ulcer Prophylaxis:
Study - Stress Ulcer bleeding prophylaxis in the Critical Care Setting: 80 mg twice daily, as a bolus infusion over a period of 15 minutes, to a maximum daily dose of 240 mg, divided into three equal doses. Study (n=20 ) - Peptic Ulcer rebleeding prophylaxis after hemostasis in the Critical Care Setting: 80 mg IV bolus, followed by continuous infusion of 8 mg/hr for 3 days, after which therapy may be continued with an oral PPI.
Usual Adult Dose for Peptic Ulcer:
Study (n=21) - Stress Ulcer bleeding prophylaxis in the Critical Care Setting: 80 mg twice daily, as a bolus infusion over a period of 15 minutes, to a maximum daily dose of 240 mg, divided into three equal doses. Study (n=20 ) - Peptic Ulcer rebleeding prophylaxis after hemostasis in the Critical Care Setting: 80 mg IV bolus, followed by continuous infusion of 8 mg/hr for 3 days, after which therapy may be continued with an oral PPI.
Generic drug is the basic drug with an active substance in it, and the name of the generic drug is same as active substance most of the times. Like Acetaminophen/Paracetemol is Generic name and it has different brand names like Tylenol, Acimol, Crocin, Calpol etc. All these Brand names contain the same Paracetemol, but the medications are manufactured by different companies, so the different brand names. Generic drug is always cheaper and affordable, and it can be replaced in place of brand name drug prescribed by the healthcare practitioner. The Generic medicine has same properties as branded medicine in terms of uses, indications, doses, side effects, so no need to worry on that. Just select the most affordable generic or branded medicine.
"Pantoprazole: the nci development therapeutics program (dtp) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/... (accessed August 28, 2018).
PTA - Frequently asked Questions
Can PTA be stopped immediately or do I have to stop the consumption gradually to ween off?
In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.
It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.
Who should not take PTA?
Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.
You should not take this medication if you are allergic to PTA or to any other benzimidazole medication such as albendazole, or mebendazole (Vermox).
To make sure you can safely take PTA, tell your doctor if you low levels of magnesium in your blood.
Some conditions must be treated long-term with PTA. The chronic use of PTA has caused stomach cancer in animal studies, but it is not known if this medication would have the same effects in humans. Talk with your doctor about your specific risk of developing stomach cancer.
Taking a PTA pump inhibitor such as PTA may increase your risk of bone fracture in the hip, wrist, or spine. This effect has occurred mostly in people who have taken the medication long term or at high doses, and in those who are age 50 and older. It is not clear whether PTA is the actual cause of an increased risk of fracture. Before you take this medication, tell your doctor if you have osteoporosis or osteopenia (low bone mineral density).
Long-term treatment with PTA may also make it harder for your body to absorb vitamin B-12, resulting in a deficiency of this vitamin. Symptoms of a vitamin B-12 deficiency may develop slowly and include pale skin, weakness, tired feeling, shortness of breath, and a fast heart rate. Talk with your doctor if you need long-term PTA treatment and you have concerns about vitamin B-12 deficiency.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
PTA can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take PTA?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
PTA tablets can be taken with or without food. PTA oral granules should be taken 30 minutes before a meal.
Do not crush, chew, or break the tablet. Swallow it whole. The enteric-coated pill has a special coating to protect your stomach. Breaking the pill will damage this coating.
The oral granules should be mixed only with applesauce or apple juice to make swallowing easy. Do not use any other type of liquid or soft food. Sprinkle the granules directly onto a teaspoon of applesauce and swallow this mixture right away without chewing. Or pour the granules into a cup with 1 teaspoon of apple juice, stir for 5 seconds and swallow right away. To make sure you get the entire dose, add a little more apple juice to the same glass, swirl gently and drink right away. Do not save the granule mixture for later use.
To give PTA granules through a nasogastric (NG) feeding tube:
Attach a 60-milliliter syringe to the NG tube and remove the plunger. Hold the syringe high enough to prevent any bends in the tube.
Sprinkle the PTA granules into the syringe barrel and mix in 2 teaspoons of apple juice. Gently tap or shake the syringe as it empties into the tube.
Add another 2 teaspoons of apple juice to the syringe to help rinse the granules through and to make sure the entire PTA dose is given. Tap or shake the syringe as the juice empties into the tube.
Repeat the rinse with 2 teaspoons of apple juice at least twice more, gently shaking the syringe as it empties into the tube. Make sure there are no granules remaining in the syringe or NG tube.
This medication can cause you to have a false positive drug-screening test. If you provide a urine sample for drug-screening, tell the laboratory staff that you are taking PTA.
Take this medication for the full prescribed length of time. Your symptoms may improve before the condition is fully treated.
Call your doctor if your symptoms do not improve or if they get worse while you are taking this medicine.
Store at room temperature away from moisture and heat.
What other drugs will affect PTA?
PTA should not be taken together with atazanavir (Reyataz) or nelfinavir (Viracept). Tell your doctor if you are taking either of these medications to treat HIV or AIDS.
Tell your doctor about all other medicines you use, especially:
ampicillin (Principen, Unasyn);
a blood thinner such as warfarin (Coumadin, Jantoven);
digoxin (Lanoxin, Lanoxicaps);
a diuretic (water pill);
ketoconazole (Nizoral);
iron (Feosol, Mol-Iron, Fergon, Femiron, others); or
methotrexate (Rheumatrex, Trexall).
This list is not complete and other drugs may interact with PTA. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Can PTA be taken or consumed while pregnant?
Please visit your doctor for a recommendation as such case requires special attention.
Can PTA be taken for nursing mothers or during breastfeeding?
Kindly explain your state and condition to your doctor and seek medical advice from an expert.
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Reviews
Following the study conducted by gmedication.com on PTA, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of PTA. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.
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