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What is Pregagamma

Pregagamma is an anti-epileptic drug, also called an anticonvulsant. It works by slowing down impulses in the brain that cause seizures. Pregagamma also affects chemicals in the brain that send pain signals across the nervous system.
Pregagamma is used to control seizures and to treat fibromyalgia. It is also used to treat pain caused by nerve damage in people with diabetes, herpes zoster (post-herpetic neuralgia), or spinal cord injury.
Pregagamma may also be used for purposes not listed in Pregagamma guide.

Pregagamma side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive, more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these serious side effects:

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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Pregagamma dosing

Usual Adult Dose for Diabetic Neuropathy:

Initial dose: 50 mg 3 times a day
The maximum recommended dose is 100 mg 3 times a day in patients with a creatinine clearance of at least 60 mL/min.
The dose may be increased to 100 mg 3 times a day within 1 week based on efficacy and tolerability.

Usual Adult Dose for Postherpetic Neuralgia:

Initial dose: 75 mg 2 times a day or 50 mg 3 times a day in patients with a creatinine clearance of at least 60 mL/min
The dose may be increased to 100 mg 3 times a day within 1 week based on efficacy and tolerability.
Maximum dose: Patients who do not experience sufficient pain relief following 2 to 4 weeks of treatment with 300 mg/day and who are able to tolerate Pregagamma, may be treated with up to 300 mg 2 times a day or 200 mg 3 times a day. Due to the dose-dependent adverse effects and the higher rate of treatment discontinuation due to adverse events, dosing above 300 mg/day should be reserved only for those patients who have ongoing pain and are tolerating 300 mg daily.

Usual Adult Dose for Epilepsy:

Initial dose: 75 mg 2 times a day or 50 mg 3 times a day
Doses of 150 mg to 600 mg/day have been shown to be effective as adjunctive therapy in the treatment of partial onset seizures. The total daily dose should be divided and given either 2 or 3 times a day.
Maximum dose: Based on individual patient response and tolerability, the dose may be increased to a maximum of 600 mg/day.
The efficacy of add-on Pregagamma in patients taking gabapentin has not been evaluated in controlled trials. Therefore, dosing recommendations for the use of Pregagamma with gabapentin cannot be offered.

Usual Adult Dose for Fibromyalgia:

Initial dose: 75 mg two times a day
The dose may be increased to 150 mg two times a day (300 mg/day) within one week based on efficacy and tolerability.
Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg two times a day (450 mg/day).
Recommended dose: 300 to 450 mg/day
Although Pregagamma was also studied at 600 mg/day, there is no evidence that this dose confers additional benefit and this dose was less well tolerated. In view of the dose-dependent adverse reactions, treatment with doses above 450 mg/day is not recommended.

Usual Adult Dose for Neuropathic Pain:

For neuropathic pain associated with spinal cord injury:
Initial dose: 75 mg 2 times a day
The dose may be increased to 150 mg 2 times a day within 1 week based on efficacy and tolerability.
Doses of 150 mg to 600 mg/day have been shown to be effective as adjunctive therapy in the treatment of neuropathic pain associated with spinal cord injury. The total daily dose should be divided.
Maximum dose: Patients who do not experience sufficient pain relief following 2 to 3 weeks of treatment with 150 mg 2 times a day and who are able to tolerate Pregagamma, may be treated with up to 300 mg 2 times a day. Because Pregagamma is eliminated primarily by renal excretion, the dose should be adjusted in patients with reduced renal function.

Select the most affordable brand or generic drug


StrengthQuantityPrice, USDCountry
75 mg10 Capsule$0.98
Gabafit 150mg CAP / 10 $1.89
GABAFIT cap 75 mg x 10's $0.98Glenmark (Healtheon)
Gabafit 100mg Capsule $0.13Glenmark Pharmaceuticals Ltd
10 's $1.96
Gabamax 75 mg Capsule $0.11
Gabanext 75mg Capsule $0.16Abbott India Ltd
GABANEXT tab 150 mg x 10's $2.02AHPL
GALINERVE cap 150 mg x 10's $1.81Sun (Arian)
Galinerve 75mg CAP / 10 $0.97
100 mg90 $336.34USA
150 mg30 $95.00
225 mg60 $225.89USA
300 mg90 $336.34USA
50 mg30 $95.00
LYRICA cap 150 mg x 14's $1.61Pfizer
LYRICA cap 75 mg x 14's $1.08Pfizer
Lyrica 50 mg x 56's $48.19
Lyrica cap 150 mg 56's $144.50Pfizer
Maxgalin 75mg Capsule $0.18Sun Pharmaceutical Industries Ltd
Maxgalin 100mg Tablet ER $0.21Sun Pharmaceutical Industries Ltd
Maxgalin 150mg Tablet ER $0.30Sun Pharmaceutical Industries Ltd
MAXGALIN cap 50 mg x 10's $0.83Sun (Sirius)
MAXGALIN cap 75 mg x 10's $1.30Sun (Sirius)
Neugaba 75mg Tablet ER $0.19Sun Pharmaceutical Industries Ltd
NEUGABA 150 MG CAPSULE 1 strip(s) (10 capsules each) $2.80Sun Pharma Laboratories Ltd
NEUGABA cap 75 mg x 10's $1.30Sun
75 mg10 Capsule$0.92
150 mg x 10's $2.31
Pregab 150mg CAP / 10 $2.31
75 mg x 10's $1.24
Pregab 75mg CAP / 10 $1.24
Lyrica 200 mg capsule $2.75
Lyrica 225 mg capsule $2.75
Lyrica 25 mg capsule $2.75
Lyrica 300 mg capsule $2.75
Lyrica 100 mg capsule $2.88
Lyrica 150 mg capsule $2.88
Lyrica 50 mg capsule $2.88
Lyrica 75 mg capsule $2.88
100 mg10 Capsule$1.60
Pregalin CAPS 100mg CAP / 10 $1.60
Pregalin CAPS 150mg CAP / 10 $2.31
Pregalin CAPS 75mg CAP / 10 $1.22
Prelin 75mg Capsule $0.14Intas Pharmaceuticals Ltd
PRELIN 150 MG CAPSULE 1 strip(s) (10 capsules each) $1.88Intas Pharmaceuticals Ltd
PRELIN 75 MG CAPSULE 1 strip(s) (10 capsules each) $1.30Intas Pharmaceuticals Ltd
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References

  1. Dailymed."Pregabalin: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "Pregabalin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "Pregabalin". http://www.drugbank.ca/drugs/DB0023... (accessed August 28, 2018).

Pregagamma - Frequently asked Questions

Can Pregagamma be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

What other drugs will affect Pregagamma?

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for depression or anxiety can add to dizziness or sleepiness caused by Pregagamma. Tell your doctor if you regularly use any of these medicines, or any other seizure medication.

Tell your doctor about all other medicines you use, especially:

This list is not complete and other drugs may interact with Pregagamma. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Who should not take Pregagamma?

You should not use this medication if you are allergic to Pregagamma.

To make sure you can safely take Pregagamma, tell your doctor if you have any of these other conditions:

You may have thoughts about suicide while taking this medication. Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

FDA pregnancy category C. It is not known whether Pregagamma will harm an unborn baby, but having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant while taking Pregagamma for seizures. Do not start or stop taking Pregagamma during pregnancy without your doctor's advice.

If you become pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Pregagamma on the baby.

It is not known whether Pregagamma passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using Pregagamma.

If a man fathers a child while using this medication, the baby may have birth defects. Use a condom to prevent pregnancy during your treatment.

Do not give this medication to a child younger than 18 years old.

How should I take Pregagamma?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

You may take Pregagamma with or without food.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not change your dose of Pregagamma without your doctor's advice. Tell your doctor if the medication does not seem to work as well in treating your condition.

Call your doctor if you have any problems with your vision while taking Pregagamma.

If you are taking Pregagamma to prevent seizures, keep taking it even if you feel fine. You may have an increase in seizures if you stop taking Pregagamma. Follow your doctor's instructions.

Do not stop using Pregagamma without first talking to your doctor, even if you feel fine. You may have increased seizures or withdrawal symptoms such as headache, sleep problems, nausea, and diarrhea. Ask your doctor how to avoid withdrawal symptoms when you stop using Pregagamma.

Wear a medical alert tag or carry an ID card stating that you take Pregagamma. Any medical care provider who treats you should know that you take seizure medication.

Store at room temperature away from moisture, light, and heat.

Can Pregagamma be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Pregagamma be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

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Reviews

Following the study conducted by gmedication.com on Pregagamma, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Pregagamma. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

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The information was verified by Dr. Vishal Pawar, MD Pharmacology