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  1. INDICATIONS
  2. DOSAGE AND ADMINISTRATION
  3. SAFETY
  4. PRECAUTIONS
  5. WARNING
  6. HUMAN WARNINGS
  7. ENVIRONMENTAL WARNINGS
  8. NOTE TO USER



Noromectin Praziquantel Duo uses

FOR ORAL USE IN HORSES ONLY
Removes worms and bots with a single dose.
Contents will treat up to 1320 lb body weight.
Net Weight: 0.225 oz (6.42 g)

INDICATIONS

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism. Equimax (ivermectin/praziquantel) Paste is indicated for the treatment and control of the following parasites:
Tapeworms
Anoplocephala perfoliata
Large Strongyles (adults)
Strongylus vulgaris (also early forms in blood vessels)
S. edentatus (also tissue stages)
S. equinus
Triodontophorus spp.
Small Strongyles (adults, including those resistant to some benzimidazole class compounds)
Cyathostomum spp.
Cylicocyclus spp.
Cylicostephanus spp.
Cylicodontophorus spp.
Small Strongyles (fourth-stage larvae)
Pinworms (adults and fourth-stage larvae)
Oxyuris equi
Ascarids (adults and third- and fourth-stage larvae)
Parascaris equorum
Hairworms (adults)
Trichostrongylus axei
Large-mouth Stomach Worms (adults)
Habronema muscae
Bots (oral and gastric stages)
Gasterophilus spp.
Lungworms (adults and fourth-stage larvae)
Dictyocaulus arnfieldi
Intestinal Threadworms (adults)
Strongyloides westeri
Summer Sores caused by Habronema and Draschia spp. cutaneous third-stage larvae
Dermatitis caused by Neck Threadworm microfilariae, Onchocerca sp.
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DOSAGE AND ADMINISTRATION

This syringe contains sufficient paste to treat one 1320-lb horse at the recommendeddose rate of 91 mcg Noromectin Praziquantel Duo per lb and 0.68 mg praziquantel per lb (1.5 mg/kg) of body weight. Each weightmarking on the syringe plunger delivers enough paste to treat 220 lb (100 kg) of body weight.

Parasite Control Program

All horses should be included in a regular parasite control program with particular attention beingpaid to mares, foals, and yearlings. Foals should be treated initially at 4 weeks of age, and routine treatment repeated asappropriate. Consult your veterinarian for a control program to meet your specific needs. Noromectin Praziquantel Duo Paste effectively controlsgastrointestinal nematodes, cestodes and bots of horses. Regular treatment will reduce the chances of colic caused byAnoplocephala perfoliata and verminous arteritis caused by Strongylus vulgaris.

Product Advantages

Broad-spectrum Control

Noromectin Praziquantel Duo Paste kills important internal parasites, including tapeworms, botsand the arterial stages of S. vulgaris, with a single dose. Noromectin Praziquantel Duo Paste contains two potent antiparasitic agents that areneither benzimidazoles nor organophosphates.
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SAFETY

Noromectin Praziquantel Duo Paste may be used in horses 4 weeks of age and older. Stallions and breeding, pregnant or lactatingmares may be treated without adverse effects on fertility.
In a tolerance study in which 3- to 4-week-old foals were treated at 10X once, loose watery stools were observed onpost-treatment days 1, 2, and 5-9 in one foal. These signs resolved without treatment by day 10, and no other foals wereaffected.
In a reproductive safety study, eleven mares were treated with a 3X dose of Noromectin Praziquantel Duo Paste every two weeks throughoutbreeding, pregnancy and lactation, up until the foal was three months of age. Ten mares served as controls and were treatedwith the vehicle paste in a similar manner. An increased incidence of colic was observed in treated mares as compared tocontrol mares. In addition, elevations of GGT and AST were more frequent in the 3X treated mares, and in two mares theseenzymes were elevated at the time of colic episodes.
One treated mare was dropped from the study because she did not conceive after three breeding attempts.
Two treated mares had abnormally short diestrous periods of two days and eight days on the first estrous cycle following thebirth of the study foal. In addition, one of these two mares failed to ovulate in the second and third estrous cycles.
In the first few weeks of life, foals born to the 3X treated mares had a higher incidence of transient ocular discharge andgastrointestinal disturbances (loose stools, diarrhea) and depression requiring medical intervention as compared to foalsborn to control mares.
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PRECAUTIONS

Noromectin Praziquantel Duo Paste has been formulated specifically for use in horses and ponies only. This product should notbe used in other animal species as severe adverse reactions, including fatalities in dogs, may result.

WARNING

Do not use in horses intended for human consumption.

HUMAN WARNINGS

Not for use in humans. Keep this and all drugs out of the reach of children. Refrain from eating orsmoking when handling. Wash hands after use. Avoid contact with eyes. The Material Safety Data Sheet (MSDS) containsmore detailed occupational safety information. To report adverse reactions in users, to obtain more information, or to obtaina MSDS, contact Bimeda Inc. at 1-888-524-6332.

ENVIRONMENTAL WARNINGS

Noromectin Praziquantel Duo and excreted Noromectin Praziquantel Duo residues may adversely affect aquatic organisms. Do notcontaminate ground or surface water. Dispose of the syringe in an approved landfill or by incineration.
Store at room temperature (25°C/77°F), with excursions permitted between 15°–30°C (59°–86°F).

NOTE TO USER

Swelling and itching reactions after treatment with Noromectin Praziquantel Duo paste have occurred in horses carrying heavyinfections of neck threadworm (Onchocerca sp. microfilariae). These reactions were most likely the result of microfilariaedying in large numbers. Symptomatic treatment may be advisable. Consult your veterinarian should any such reactionsoccur. Healing of summer sores involving extensive tissue changes may require other appropriate therapy in conjunctionwith treatment with Noromectin Praziquantel Duo Paste. Reinfection, and measures for its prevention, should also be considered. Consult yourveterinarian if the condition does not improve.
To report adverse reactions, call Bimeda Inc. at 1-888-524-6332.
NADA #141-215, Approved by FDA
Manufactured by:
Virbac AH Inc.
3200 Meacham Blvd
Fort Worth, Texas 76137
U.S. Patent No. 5,824,653
Distributed by:
Bimeda, Inc.
Le Sueur, MN 56058
Made in USA
Noromectin Praziquantel Duo is a Registered Trademark of Virbac SA.
301985-01
October 2009

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References

  1. Dailymed."Praziquantel: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "Praziquantel". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "Praziquantel". http://www.drugbank.ca/drugs/DB0105... (accessed August 28, 2018).

Noromectin Praziquantel Duo - Frequently asked Questions

Can Noromectin Praziquantel Duo be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

Can Noromectin Praziquantel Duo be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Noromectin Praziquantel Duo be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

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Reviews

Following the study conducted by gmedication.com on Noromectin Praziquantel Duo, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Noromectin Praziquantel Duo. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

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The information was verified by Dr. Vishal Pawar, MD Pharmacology