Ceftriaxone (Lezone-S) is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body. Ceftriaxone (Lezone-S) is used to treat many kinds of bacterial infections, including severe or life-threatening forms such as meningitis. Ceftriaxone (Lezone-S) may also be used for purposes not listed in Ceftriaxone (Lezone-S) guide.
Ceftriaxone (Lezone-S) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
diarrhea that is watery or bloody;
fever, chills, swollen glands, rash or itching, joint pain, or general ill feeling;
white patches or sores inside your mouth or on your lips;
unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
pale or yellowed skin, dark colored urine, confusion or weakness;
urinating less than usual or not at all;
seizure (convulsions);
swelling, pain, or irritation where the injection was given;
chalky-colored stools, stomach pain just after eating a meal, nausea, heartburn, bloating, and severe upper stomach pain that may spread to your back; or
severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Less serious side effects may include:
a hard lump where the injection was given;
nausea, vomiting, upset stomach;
headache, dizziness, overactive reflexes;
pain or swelling in your tongue;
sweating; or
vaginal itching or discharge.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. See also: Side effects (in more detail)
advertisement
Ceftriaxone (Lezone-S) dosing
Usual Adult Dose for Bacterial Infection:
Usual daily dose: 1 to 2 g/day IV or IM in 1 to 2 divided doses, depending on the nature and severity of the infection For infections caused by Staphylococcus aureus, the recommended dose is 2 to 4 g/day, in order to achieve greater than 90% target attainment. The total daily dose should not exceed 4 g.
Usual Adult Dose for Bacteremia:
2 g IV every 24 hours for 14 days, depending on the nature and severity of the infection
Usual Adult Dose for Chancroid:
250 mg IM as a single dose The causative organism is Haemophilus ducreyi. HIV-infected patients may require longer treatment. Ceftriaxone should only be given if patient follow-up can be guaranteed. Patients should be retested for syphilis and HIV in 3 months, if initial tests were negative. The patient's sexual partner(s) should also be evaluated/treated.
Usual Adult Dose for Conjunctivitis:
Gonococcal Conjunctivitis: 1 g IM once Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection. The patient's sexual partner(s) should also be evaluated/treated.
Usual Adult Dose for Endocarditis:
Patients with normal renal function: Native valve infections due to highly penicillin-susceptible viridans Group Streptococci and S bovis : Ceftriaxone (Lezone-S) 2 g IV or IM every 24 hours for 4 weeks plus gentamicin 3 mg/kg IV or IM every 24 hours for 2 weeks Native valve infections due to relatively resistant S viridans and S bovis (MIC greater than 0.12 mcg/mL and 0.5 mcg/mL or less): Ceftriaxone (Lezone-S) 2 g IV or IM every 24 hours for 4 weeks plus gentamicin 3 mg/kg IV or IM every 24 hours for 2 weeks Prosthetic valve infections due to penicillin-susceptible S viridans and S bovis (MIC 0.12 mcg/mL or less): Ceftriaxone (Lezone-S) 2 g IV or IM every 24 hours for 6 weeks plus gentamicin 3 mg/kg IV or IM every 24 hours for 2 weeks Prosthetic valve infections due to relatively or fully penicillin-resistant S viridans and S bovis (MIC greater than 0.12 mcg/mL): Ceftriaxone (Lezone-S) 2 g IV or IM every 24 hours for 6 weeks plus gentamicin 3 mg/kg IV or IM every 24 hours for 6 weeks Native or prosthetic valve infections due to enterococcal strains resistant to penicillin, aminoglycosides, and vancomycin: Ceftriaxone (Lezone-S) 2 g IV or IM every 24 hours plus ampicillin 2 g IV every 4 hours for 8 weeks or more Gonococcal endocarditis: 1 to 2 g IV every 12 hours for at least 4 weeks Refer to current published guidelines for detailed recommendations.
Usual Adult Dose for Bacterial Endocarditis Prophylaxis:
As an alternative in patients unable to take oral medication, with or without penicillin allergy (non-anaphylactoid type): 1 g IV or IM once 30 to 60 minutes before procedure
Usual Adult Dose for Endometritis:
2 g IV every 24 hours plus clindamycin Duration: Parenteral therapy should be continued for at least 24 hours after the patient has remained afebrile, pain free, and the leukocyte count has normalized. Doxycycline therapy for 14 days is recommended if concurrent chlamydial infection is present in late postpartum patients.
Usual Adult Dose for Epididymitis -- Sexually Transmitted:
Gonococcal epididymitis: 250 mg IM as a single dose Doxycycline 100 mg twice daily orally for 10 days should be given to treat a concurrent chlamydial infection. The patient's sexual partner(s) should also be evaluated/treated.
Usual Adult Dose for Epiglottitis:
2 g IV every 24 hours for 7 to 10 days, depending on the nature and severity of the infection
Usual Adult Dose for Gastroenteritis:
2 g IV every 24 hours Duration: 7 to 10 days in immunocompromised patients
Usual Adult Dose for Gonococcal Infection -- Disseminated:
1 g IV or IM every 24 hours Duration: Parenteral therapy should be continued for 24 to 48 hours after clinical improvement is demonstrated. Oral therapy with cefixime should then be continued to complete a total course of at least 1 week. Doxycycline therapy for 7 days or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection. The patient's sexual partner(s) should also be evaluated/treated.
Usual Adult Dose for Gonococcal Infection -- Uncomplicated:
Uncomplicated infections of the cervix, urethra, rectum, or pharynx: 250 mg IM once Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection. The patient's sexual partner(s) should also be evaluated/treated.
Usual Adult Dose for Intraabdominal Infection:
2 g IV every 24 hours for 7 to 14 days, depending on the nature and severity of the infection
Usual Adult Dose for Joint Infection:
1 to 2 g IV or IM every 24 hours Duration: 3 to 4 weeks, depending on the nature and severity of the infection; longer therapy, 6 weeks or more, may be required for prosthetic joint infections
Usual Adult Dose for Lyme Disease -- Arthritis:
2 g IV or IM every 24 hours Febrile patients should also be evaluated/treated for human granulocytic ehrlichiosis and babesiosis. Duration: 14 days for arthritis, up to 21 days for carditis, and up to 30 days for neurologic Lyme disease
Usual Adult Dose for Lyme Disease -- Carditis:
2 g IV or IM every 24 hours Febrile patients should also be evaluated/treated for human granulocytic ehrlichiosis (HGE) and babesiosis. Duration: 14 days for arthritis, up to 21 days for carditis, and up to 30 days for neurologic Lyme disease
Usual Adult Dose for Lyme Disease -- Neurologic:
2 g IV or IM every 24 hours Febrile patients should also be evaluated/treated for human granulocytic ehrlichiosis and babesiosis. Duration: 14 days for arthritis, up to 21 days for carditis, and up to 30 days for neurologic Lyme disease
Usual Adult Dose for Meningitis:
2 g IV every 12 hours for 14 days, depending on the nature and severity of the infection Gonococcal meningitis: 1 to 2 g IV every 12 hours for 10 to 14 days
Usual Adult Dose for Meningococcal Meningitis Prophylaxis:
250 mg IM once
Usual Adult Dose for Neurosyphilis:
2 g IV or IM every 24 hours for 10 to 14 days Aqueous crystalline penicillin G is considered the drug of choice by the CDC. The patient's sexual partner should also be evaluated/treated.
Usual Adult Dose for Osteomyelitis:
1 to 2 g IV or IM every 24 hours Duration: 4 to 6 weeks, depending on the nature and severity of the infection; additional oral antibiotic therapy may be required for up to 6 months for chronic osteomyelitis
Usual Adult Dose for Pelvic Inflammatory Disease:
Outpatient treatment of mild PID: 250 mg IM once plus oral doxycycline with or without metronidazole Severe: 1 to 2 g IV or IM every 24 hours for 14 days, depending on the nature and severity of the infection Doxycycline therapy for 14 days is also recommended to treat possible concurrent chlamydial infection. The patient's sexual partner(s) should also be evaluated/treated.
Usual Adult Dose for Peritonitis:
2 g IV every 24 hours Peritoneal dialysis-related peritonitis: Continuous: 1 g/2 L dialysate intraperitoneally, followed by 250 to 500 mg/2 L dialysate Intermittent: 1 g/2 L dialysate intraperitoneally every 24 hours Duration: 10 to 14 days, depending on the nature and severity of the infection
Usual Adult Dose for Pneumonia:
1 to 2 g IV or IM every 24 hours for 7 to 21 days, depending on the nature and severity of the infection
Usual Adult Dose for Prostatitis:
Gonococcal prostatitis: 250 mg IM once Doxycycline 100 mg twice daily orally for 10 days should be given to treat a concurrent chlamydial infection. The patient's sexual partner should also be evaluated/treated.
Usual Adult Dose for Pyelonephritis:
1 to 2 g IV or IM every 24 hours Duration: 14 days, depending on the nature and severity of the infection
Usual Adult Dose for Salmonella Gastroenteritis:
2 g IV every 24 hours Duration: Up to 14 days in immunocompromised patients, or longer if a relapse occurs
Usual Adult Dose for Sepsis:
Severe: 2 g IV every 24 hours for 14 days, depending on the nature and severity of the infection
Usual Adult Dose for Skin or Soft Tissue Infection:
Severe: 1 to 2 g IV or IM every 24 hours Duration: 7 to 10 days, depending on the nature and severity of the infection; diabetic soft tissue infections may require treatment for 14 to 21 days
Usual Adult Dose for STD Prophylaxis:
STD prophylaxis, sexual assault: 250 mg IM once, in combination with metronidazole and azithromycin or doxycycline Sexual partner of patients with chancroid: 250 mg IM once
Usual Adult Dose for Surgical Prophylaxis:
1 g IV once 30 to 120 minutes before surgery Third generation cephalosporins are generally not recommended for routine surgical prophylaxis.
Usual Adult Dose for Syphilis -- Early:
1 g IV or IM every 24 hours for 10 to 14 days Benzathine penicillin G is considered the drug of choice by the CDC. The patient's sexual partner should also be evaluated/treated.
Usual Adult Dose for Typhoid Fever:
2 g IV every 24 hours Duration: 7 to 10 days; if the patient is immunocompromised or a relapse occurs, 14 days or more of treatment may be required
Usual Adult Dose for Urinary Tract Infection:
Severe: 1 to 2 g IV or IM every 24 hours Duration: 2 to 3 weeks for complicated infections
Usual Pediatric Dose for Bacterial Infection:
Less than 1 week: 50 mg/kg IV or IM every 24 hours 1 to 4 weeks, 2000 g or less: 50 mg/kg IV or IM every 24 hours 1 to 4 weeks, greater than 2000 g: 50 to 75 mg/kg IV or IM every 24 hours Ceftriaxone should be avoided in neonates with hyperbilirubinemia. 1 month or older: Severe: 50 to 75 mg/kg IV in divided doses every 12 to 24 hours (maximum dose: 2 g/24 hours) Life-threatening: 80 to 100 mg/kg IV in 1 or 2 divided doses (maximum dose: 4 g/24 hours)
Usual Pediatric Dose for Gonococcal Infection -- Uncomplicated:
Infants of mothers with gonococcal infection (gonococcal prophylaxis): 25 to 50 mg/kg (maximum dose: 125 mg) IV or IM once Ceftriaxone (Lezone-S) should be avoided in neonates with hyperbilirubinemia. Infant and mother should be evaluated/treated for possible concurrent chlamydial infection. The mother's sexual partner(s) should also be evaluated/treated. Children with uncomplicated infections of the vulva and vagina, cervix, urethra, rectum, or pharynx: 45 kg or less: 125 mg IM once Greater than 45 kg: 250 mg IM once Patients should be evaluated/treated for possible concurrent syphilis and/or chlamydial infections.
Usual Pediatric Dose for Gonococcal Infection -- Disseminated:
0 to 4 weeks: 25 to 50 mg/kg IV or IM every 24 hours for 7 days, up to 10 to 14 days if meningitis is documented Ceftriaxone (Lezone-S) should be avoided in neonates with hyperbilirubinemia. 1 month or older: 45 kg or less: Arthritis or bacteremia: 50 mg/kg (maximum dose: 1 g) IV or IM every 24 hours for 7 days Greater than 45 kg: 1 g IV or IM once a day for 7 days Patients should be evaluated/treated for possible concurrent syphilis and/or chlamydial infections.
Usual Pediatric Dose for Meningitis:
0 to 4 weeks: 50 to 75 mg/kg every 24 hours Ceftriaxone (Lezone-S) should be avoided in neonates with hyperbilirubinemia. 1 month or older: Initial dose: 100 mg/kg IV at the start of therapy (maximum dose: 4 g) Maintenance dose: 100 mg/kg/day IV once a day or in divided doses every 12 hours for 7 to 14 days (maximum dose: 4 g/24 hours) Gonococcal infection: 45 kg or less: 50 mg/kg/day IV or IM divided every 12 hours for 10 to 14 days (maximum dose: 2 g/day) Greater than 45 kg: 1 to 2 g IV or IM every 12 hours for 10 to 14 days
Usual Pediatric Dose for Meningococcal Meningitis Prophylaxis:
Less than 15 years: 125 mg IM once 15 years or older: 250 mg IM once
Usual Pediatric Dose for Endocarditis:
Gonococcal infection: 45 kg or less: 50 mg/kg/day IV or IM divided every 12 hours for at least 28 days Greater than 45 kg: 1 to 2 g IV or IM every 12 hours for at least 28 days
Usual Pediatric Dose for Bacterial Endocarditis Prophylaxis:
As an alternative in patients unable to take oral medication, with or without penicillin allergy (non-anaphylactoid type): 50 mg/kg (maximum dose: 1 g) IV or IM once 30 to 60 minutes before procedure
Usual Pediatric Dose for Otitis Media:
Acute bacterial otitis media: 50 mg/kg IM once Persistent or relapsing acute otitis media: 50 mg/kg IV or IM once a day for 3 days (maximum dose: 1 g/day) Ceftriaxone (Lezone-S) should be avoided in neonates with hyperbilirubinemia.
Usual Pediatric Dose for Epiglottitis:
1 month or older: 50 to 100 mg/kg IV or IM once a day Duration: Has been reported to range from 2 to 14 days
Usual Pediatric Dose for Skin and Structure Infection:
1 month or older: 50 to 75 mg/kg/day IV or IM in 1 to 2 divided doses
Usual Pediatric Dose for Typhoid Fever:
1 month or older: 75 to 80 mg/kg IV once a day for 5 to 14 days
Usual Pediatric Dose for Lyme Disease:
Persistent arthritis, meningitis, encephalitis: 75 to 100 mg/kg/day IV or IM for 2 to 4 weeks
Usual Pediatric Dose for Salmonella Gastroenteritis:
50 to 75 mg/kg/day IV for 2 to 5 days Treat immunocompromised patients for up to 10 days. Ceftriaxone (Lezone-S) should be avoided in neonates with hyperbilirubinemia.
Usual Pediatric Dose for Shigellosis:
50 to 75 mg/kg/day IV for 2 to 5 days Treat immunocompromised patients for up to 10 days. Ceftriaxone should be avoided in neonates with hyperbilirubinemia.
Usual Pediatric Dose for STD Prophylaxis:
STD prophylaxis, sexual assault: 13 years or older: 250 mg IM once, in combination with metronidazole and azithromycin or doxycycline
Usual Pediatric Dose for Conjunctivitis:
Gonococcal infection: Neonates: 25 to 50 mg/kg IV or IM once 1 month or older: 45 kg or less: 50 mg/kg (maximum dose: 1 g) IV or IM once Greater than 45 kg: 1 g IM once
Usual Pediatric Dose for Chancroid:
1 month or older: 50 mg/kg (maximum dose: 250 mg) IM as a single dose
Usual Pediatric Dose for Epididymitis -- Non-Specific:
Dailymed."Ceftriaxone sodium: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
Can Lezone-S be stopped immediately or do I have to stop the consumption gradually to ween off?
In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.
It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.
How should I take Ceftriaxone (Lezone-S)?
Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Ceftriaxone (Lezone-S) is injected into a muscle, or into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.
Ceftriaxone (Lezone-S) must be given slowly, and the IV infusion can take at least 30 minutes to complete.
You may need to mix Ceftriaxone (Lezone-S) with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication. Use only the diluent your doctor has recommended.
After mixing your medicine, you will need to use it within a certain number of hours or days. This will depend on the diluent and how you store the mixture (at room temperature, in a refrigerator, or frozen). Carefully follow the mixing and storage instructions provided with your medicine. Ask your pharmacist if you have questions.
Do not mix Ceftriaxone (Lezone-S) in the same injection with other antibiotics, or with any diluent that contains calcium, including a TPN (total parenteral nutrition) solution.
If you use other injectable medications, be sure to flush your intravenous catheter between injections of each medication.
Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ceftriaxone (Lezone-S) will not treat a viral infection such as the common cold or flu.
This medication can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using Ceftriaxone (Lezone-S).
Store unmixed Ceftriaxone (Lezone-S) powder at room temperature, away from moisture, heat, and light.
If your medicine was provided in a frozen form or was frozen after mixing, thaw it in a refrigerator or at room temperature. Do not warm in a microwave or boiling water. Use the medicine as soon as possible after thawing it. Do not refreeze.
What other drugs will affect Ceftriaxone (Lezone-S)?
There may be other drugs that can interact with Ceftriaxone (Lezone-S). Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Who should not take Ceftriaxone (Lezone-S)?
Do not use this medication if you are allergic to Ceftriaxone (Lezone-S), or to other cephalosporin antibiotics, such as:
cefaclor (Raniclor);
cefadroxil (Duricef);
Ceftriaxone (Lezone-S) (Ancef);
cefdinir (Omnicef);
cefditoren (Spectracef);
cefpodoxime (Vantin);
cefprozil (Cefzil);
ceftibuten (Cedax);
cefuroxime (Ceftin);
cephalexin (Keflex); or
cephradine (Velosef).
To make sure you can safely use Ceftriaxone (Lezone-S), tell your doctor if you have any of these other conditions:
kidney disease (or if you are on dialysis);
liver disease;
diabetes;
gallbladder disease;
a stomach or intestinal disorder such as colitis;
if you are malnourished; or
if you are allergic to penicillin.
FDA pregnancy category B. Ceftriaxone (Lezone-S) is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Ceftriaxone (Lezone-S) can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Do not use Ceftriaxone (Lezone-S) in a child without a doctor's advice, and never give more than the child's prescribed dose. Ceftriaxone (Lezone-S) should never be used in a newborn with jaundice.
Can Lezone-S be taken or consumed while pregnant?
Please visit your doctor for a recommendation as such case requires special attention.
Can Lezone-S be taken for nursing mothers or during breastfeeding?
Kindly explain your state and condition to your doctor and seek medical advice from an expert.
advertisement
Reviews
Following the study conducted by gmedication.com on Lezone-S, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Lezone-S. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.
Patient reports
Patient reported useful
No survey data has been collected yet
Patient reported side effects
No survey data has been collected yet
Patient reported price estimates
No survey data has been collected yet
Patient reported frequency of use
No survey data has been collected yet
Patient reported doses
No survey data has been collected yet
Patient reported time for results
No survey data has been collected yet
Patient reported administration
No survey data has been collected yet
Patient reported age
No survey data has been collected yet
Patient reviews
There are no reviews yet. Be the first to write one!