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Filgrastim |
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What is Filgrastim
Filgrastim is a human granulocyte colony-stimulating factor (G-CSF) produced by recombinant DNA technology. Filgrastim® is the Amgen Inc. trademark for Filgrastim which has been selected as the name for recombinant methionyl human granulocyte colony-stimulating factor (r-metHuG-CSF). Filgrastim® is a 175 amino acid protein manufactured by recombinant DNA technology. 1 Filgrastim® is produced by Escherichia coli (E coli) bacteria into which has been inserted the human granulocyte colony-stimulating factor gene.Filgrastim® is indicated to decrease the incidence of infection as manifested by febrile neutropenia in patients with nonmyeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a significant incidence of severe neutropenia with fever (see CLINICAL EXPERIENCE). A complete blood count (CBC) and platelet count should be obtained prior to chemotherapy and twice per week (see LABORATORY MONITORING) during Filgrastim® therapy to avoid leukocytosis and to monitor the neutrophil count. In phase 3 clinical studies Filgrastim® therapy was discontinued when the ANC was > 10000/mm3 after the expected chemotherapy-induced nadir.
Filgrastim® is indicated for reducing the time to neutrophil recovery and the duration of fever, following induction or consolidation chemotherapy treatment of adults with AML.
Filgrastim® is indicated to reduce the duration of neutropenia and neutropenia-related clinical sequelae eg febrile neutropenia in patients with nonmyeloid malignancies undergoing myeloablative chemotherapy followed by marrow transplantation (see CLINICAL EXPERIENCE). It is recommended that CBCs and platelet counts be obtained at a minimum of 3 times per week (see LABORATORY MONITORING) following marrow infusion to monitor the recovery of marrow reconstitution.
Filgrastim® is indicated for the mobilization of hematopoietic progenitor cells into the peripheral blood for collection by leukapheresis. Mobilization allows for the collection of increased numbers of progenitor cells capable of engraftment compared with collection by leukapheresis without mobilization or bone marrow harvest. After myeloablative chemotherapy the transplantation of an increased number of progenitor cells can lead to more rapid engraftment which may result in a decreased need for supportive care (see CLINICAL EXPERIENCE).
Filgrastim® is indicated for chronic administration to reduce the incidence and duration of sequelae of neutropenia (eg fever infections oropharyngeal ulcers) in symptomatic patients with congenital neutropenia cyclic neutropenia or idiopathic neutropenia (see CLINICAL EXPERIENCE). It is essential that serial CBCs with differential and platelet counts and an evaluation of bone marrow morphology and karyotype be performed prior to initiation of Filgrastim® therapy (see WARNINGS). The use of Filgrastim® prior to confirmation of SCN may impair diagnostic efforts and may thus impair or delay evaluation and treatment of an underlying condition other than SCN causing the neutropenia.
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Filgrastim - Frequently asked Questions
Can Filgrastim be stopped immediately or do I have to stop the consumption gradually to ween off?
In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.
It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.
Can Filgrastim be taken or consumed while pregnant?
Please visit your doctor for a recommendation as such case requires special attention.
Can Filgrastim be taken for nursing mothers or during breastfeeding?
Kindly explain your state and condition to your doctor and seek medical advice from an expert.
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Reviews
Following the study conducted by gmedication.com on Filgrastim, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Filgrastim. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.Patient reports
Patient reported useful
No survey data has been collected yetPatient reported side effects
No survey data has been collected yetPatient reported price estimates
No survey data has been collected yetPatient reported frequency of use
No survey data has been collected yetTwo patients reported doses
What is the specific doses you have used?Filgrastim May come in various doses. In most cases, antibiotics, antihypertensive, pain killers and anti-diabetic drugs available in different doses. Your doctor may prescribe any of the doses based on the severity of the patient's condition. According to our reports, users of gmedication.com used the drugs in the following dosage percentage (Provide dosage percentage). Only a handful of drugs are made in a single or fixed dose. Regular health conditions like fever have similar doses. For instance [acetaminophen, 500mg] was used by the patients surveyed although it comes in different doses.
| Patients | % | ||
|---|---|---|---|
| 11-50mg | 2 | 100.0% | |
One patient reported time for results
How long will I use Filgrastim before I begin to notice the effect?According to the report by users of gmedication.com, about 5 days and a few days was the most common time duration among the participants, before they began to feel relief in their health conditions. It is noteworthy that you may not get the same result with other users within the same time frame. Several factors determine the timeframe; hence we implore you to consult your medical expert to get professional advice on how long you should expect to see improvement while consuming Filgrastim. However, if you wish to get the response of other users on the time effectiveness of using Filgrastim kindly click here
| Patients | % | ||
|---|---|---|---|
| 5 days | 1 | 100.0% | |
Patient reported administration
No survey data has been collected yetPatient reported age
No survey data has been collected yetPatient reviews
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The information was verified by Dr. Vishal Pawar, MD Pharmacology