Etidronate tablets contain either 200 mg or 400 mg of Etidronate disodium, the disodium salt of (1-hydroxyethylidene) diphosphonic acid, for oral administration. This compound, also known as EHDP, regulates bone metabolism. Etidronate is indicated for the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury. Etidronate is not approved for the treatment of osteoporosis. Paget's Disease: Etidronate is indicated for the treatment of symptomatic Paget's disease of bone. Etidronate therapy usually arrests or significantly impedes the disease process as evidenced by:
Symptomatic relief, including decreased pain and/or increased mobility (experienced by 3 out of 5 patients).
Reductions in serum alkaline phosphatase and urinary hydroxyproline levels (30% or more in 4 out of 5 patients).
Histomorphometry showing reduced numbers of osteoclasts and osteoblasts, and more lamellar bone formation.
Bone scans showing reduced radionuclide uptake at pagetic lesions.
In addition, reductions in pagetically elevated cardiac output and skin temperature have been observed in some patients. In many patients, the disease process will be suppressed for a period of at least 1 year following cessation of therapy. The upper limit of this period has not been determined. The effects of the Etidronate treatment in patients with asymptomatic Paget's disease have not been studied. However, Etidronate treatment of such patients may be warranted if extensive involvement threatens irreversible neurologic damage, major joints, or major weight-bearing bones. Heterotopic Ossification: Etidronate is indicated in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury. Etidronate reduces the incidence of clinically important heterotopic bone by about two-thirds. Among those patients who form heterotopic bone, Etidronate retards the progression of immature lesions and reduces the severity by at least half. Follow-up data (at least 9 months posttherapy) suggest these benefits persist. In total hip replacement patients, Etidronate does not promote loosening of the prosthesis or impede trochanteric reattachment. In spinal cord injury patients, Etidronate does not inhibit fracture healing or stabilization of the spine.
Can Etidronate be stopped immediately or do I have to stop the consumption gradually to ween off?
In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.
It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.
Can Etidronate be taken or consumed while pregnant?
Please visit your doctor for a recommendation as such case requires special attention.
Can Etidronate be taken for nursing mothers or during breastfeeding?
Kindly explain your state and condition to your doctor and seek medical advice from an expert.
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