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What is Chlorazin

Chlorazin is an anti-psychotic medication in a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain.
Chlorazin is used to treat psychotic disorders such as schizophrenia or manic-depression, and severe behavioral problems in children ages 1 through 12.
Chlorazin is also used to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus.
Chlorazin may also be used for purposes not listed in Chlorazin guide.

Chlorazin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
High doses or long-term use of Chlorazin can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take Chlorazin, the more likely you are to develop a serious movement disorder. The risk of this side effect is higher in women and older adults.
Call your doctor at once if you have:

Older adults may be more likely to have side effects from Chlorazin.
Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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Chlorazin dosing

Usual Adult Dose for Psychosis:

IM: Initial Dose 25 to 50 mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed.
Oral: Initial Dose: 10 to 25 mg orally 3 times a day. Total daily doses should be increased in 20 to 50 mg increments every 3 or 4 days until symptoms are controlled.
Usual Maintenance Dose: 200 mg/day orally
Some patients require higher dosages. Increase dosage gradually until symptoms are controlled. Maximum improvement may not be seen for weeks or even months. Continue optimum dosage for 2 weeks, then gradually reduce dosage to the lowest effective maintenance level.

Usual Adult Dose for Mania:

Oral: 10 mg orally 3 to 4 times a day or 25 mg orally 2 to 3 times a day.
More severe cases: 25 mg orally 3 times a day.
After 1 to 2 days, dose may be increased by 20 to 50 mg/day at semiweekly intervals.
Prompt control of severe symptoms: 25 mg IM one time.
If necessary, repeat in 1 hour. Subsequent doses should be oral, 25 to 50 mg three times a day.
IM: 25 mg injection one time. If necessary, may give additional 25 to 50 mg injection in 1 hour.
Increase subsequent doses gradually over several days up to 400 mg every 4 to 6 hours in exceptionally severe cases.
Usually patient becomes quiet and cooperative within 24 to 48 hours and oral doses may be substituted.
Oral: 500 mg/day is generally sufficient. Gradual increases to 2000 mg/day or more may be necessary.
There is usually little therapeutic gain to be achieved by exceeding 1000 mg/day for extended periods.
Less acutely disturbed Oral: 25 mg three times a day.
May increase gradually until effective dose is reached, usually 400 mg/day.

Usual Adult Dose for Nausea/Vomiting:

Oral: 10 to 25 mg every 4 to 6 hours as needed. May increase, if necessary.
IM: 25 mg one time. If no hypotension occurs, give 25 to 50 mg every 3 to 4 hours as needed, then switch to oral dosage.
Rectal: One 100 mg suppository every 6 to 8 hours as needed. In some patients, half this dose will do.
Nausea/Vomiting During Surgery:
IM: 12.5 mg one time. May repeat in 30 minutes if necessary and if no hypotension occurs.
IV: 2 mg at 2 minute intervals. Do not exceed 25 mg. Dilute to 1 mg/mL.

Usual Adult Dose for Light Sedation:

For light sedation prior to a medical or surgical procedure:
Oral: 25 to 50 mg, 2 to 3 hours before the operation.
IM: 12.5 to 25 mg, 1 to 2 hours before operation.

Usual Adult Dose for Hiccups:

Oral: 25 to 50 mg 3 to 4 times a day.
IM: If symptoms persist for 2 to 3 days, give 25 to 50 mg IM.
IV infusion: Should symptoms persist, use slow IV infusion: 25 to 50 mg in 500 to 1000 mL of saline.

Usual Adult Dose for Porphyria:

Oral: 25 to 50 mg 3 to 4 times a day.
Can usually be discontinued after several weeks, but maintenance therapy may be necessary for some patients.
IM: 25 mg injection 3 to 4 times a day until patient can take oral therapy.

Usual Adult Dose for Tetanus:

IM: 25 to 50 mg given 3 to 4 times daily, usually in conjunction with barbiturates. Total doses and frequency of administration must be determined by the patient's response, starting with low doses and increasing gradually.
IV: 25 to 50 mg diluted to at least 1 mg/mL and administered at a rate of 1 mg/min.

Usual Pediatric Dose for Opiate Withdrawal:

less than 1 month:
Neonatal abstinence syndrome :
Intramuscular: Initial: 0.55 mg/kg/dose given every 6 hours; change to oral after approximately 4 days, decrease dose gradually over 2 to 3 weeks. Note: Chlorazin is rarely used for neonatal abstinence syndrome due to adverse effects such as hypothermia, cerebellar dysfunction, decreased seizure threshold, and eosinophilia; other agents are preferred.

Usual Pediatric Dose for Schizophrenia:

6 months and older:
Oral: 0.5 to 1 mg/kg/dose orally every 4 to 6 hours; older children may require 200 mg/day or higher
intramuscular or intravenous: 0.5 to 1 mg/kg/dose every 6 to 8 hours
Maximum recommended doses:
less than 5 years (less than 22.7 kg): 40 mg/day
5 years and older: (22.7 to 45.5 kg): 75 mg/day

Usual Pediatric Dose for Nausea/Vomiting:

Nausea and vomiting:
Oral: 0.5 to 1 mg/kg/dose every 4 to 6 hours as needed
intramuscular or intravenous: 0.5 to 1 mg/kg/dose every 6 to 8 hours;
Maximum recommended doses:
less than 5 years : 40 mg/day
5 and older (22.7-45.5 kg): 75 mg/day

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References

  1. Dailymed."Chlorpromazine: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "Chlorpromazine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "Chlorpromazine". http://www.drugbank.ca/drugs/DB0047... (accessed August 28, 2018).

Chlorazin - Frequently asked Questions

Can Chlorazin be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

How should I take Chlorazin?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Chlorazin.

If you need to have any type of x-ray scan or MRI of your spinal cord, tell the doctor ahead of time that you are using Chlorazin. You may need to stop using the medicine for a short time.

Do not stop using Chlorazin suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using Chlorazin.

Store at room temperature away from moisture and heat.

Who should not take Chlorazin?

You should not use this medicine if you are allergic to Chlorazin or other phenothiazines.

Do not take Chlorazin if you have recently used large amounts of alcohol or taken a medicine that makes you sleepy.

Chlorazin is not approved for use in psychotic conditions related to dementia. Chlorazin may increase the risk of death in older adults with dementia-related conditions.

To make sure Chlorazin is safe for you, tell your doctor if you have:

Talk with your doctor before giving Chlorazin to a child who has been ill with a fever or flu symptoms.

Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are taking Chlorazin.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Chlorazin, do not stop taking it without your doctor's advice.

Chlorazin can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

What other drugs will affect Chlorazin?

Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking Chlorazin with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with Chlorazin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Can Chlorazin be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Chlorazin be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

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Reviews

Following the study conducted by gmedication.com on Chlorazin, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Chlorazin. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

Patient reports

One patient reported useful

How active was the Chlorazin in relieving patients of the disease or symptoms?
Based on the survey reports from users of gmedication.com, about Not useful percentage of users claimed the Chlorazin were useful to them in reducing their symptoms and diseases. However, the effectiveness of the medicine is influenced by many factors like the perception of the symptom, the severity of the conditions, and some other factors; the brand name could also be a factor to an extent. In the event the medicine does not produce the same effective result in your case, ensure you consult your medical expert to reexamine you on your disease or symptoms and prescribe, after that, alternative medications.
Patients%
Not useful1
100.0%


One patient reported side effects

Does the Chlorazin Have Any Side Effects?
Based on the survey report from users of gmedication.com, about It has side effects number of people suffered some side effect after consumption of Chlorazin. All drugs have a portion of undesirable side effects. These effects could be irritations too insignificant for the patient to even notice. However, the side effects of drugs may be determined by several factors like severity of disease and conditions associated with individual patients. However, one of the biggest factors is the dosage consumed. The higher the quantity taken by an individual, the greater the healing effect and the corresponding side effect. All patients have their different intensity of side effects. Ensure you consult your health care provider immediately you notice an unusual side effect affect the consumption of Chlorazin.
Patients%
It has side effects1
100.0%


Patient reported price estimates

No survey data has been collected yet


Patient reported frequency of use

No survey data has been collected yet


One patient reported doses

What is the specific doses you have used?
Chlorazin May come in various doses. In most cases, antibiotics, antihypertensive, pain killers and anti-diabetic drugs available in different doses. Your doctor may prescribe any of the doses based on the severity of the patient's condition. According to our reports, users of gmedication.com used the drugs in the following dosage percentage (Provide dosage percentage). Only a handful of drugs are made in a single or fixed dose. Regular health conditions like fever have similar doses. For instance [acetaminophen, 500mg] was used by the patients surveyed although it comes in different doses.
Patients%
51-100mg1
100.0%


Patient reported time for results

No survey data has been collected yet


Patient reported administration

No survey data has been collected yet


Patient reported age

No survey data has been collected yet


Patient reviews


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The information was verified by Dr. Vishal Pawar, MD Pharmacology